Go back to sleep… there is no possible connection… none whatsoever…


GENRE: Research item

TO: Various Bcc Email lists

AUTHOR: Daniel Z

DATE SENT:  Sat, Mar 16, 2013 at 2:31 AM

TITLE:  Go back to sleep… there is no possible connection… none whatsoever…

STATUS: None required – research item.

UPDATES: Please place any updates into the COMMENTS section below

EXTERNAL LINK: http://www.newscientist.com/article/dn4045-copper-link-to-alzheimers-disease.html

To: Various Bcc lists

In the latest experiments, the cholesterol-fed rabbits were given water laced with 0.12 parts per million copper, one tenth of US safety limit for humans. Three-quarters of the rabbits showed senile plaque-like deposits in their brains after 10 weeks. These rabbits also showed an 80 per cent deficit in memory in complex conditioning tests.

The plaques were not found in the brains of animals given pure distilled water and were rare among those drinking tap water.

“Although we can only speculate about how the effects of copper consumption in cholesterol-fed rabbits relate to those in humans, it is of note that the levels of copper … that induced beta-amyloid and senile plaque-like structures are well below those considered safe for humans,” Sparks and Schreurs write in Proceedings of the National Academy of Sciences:

Sparks says the pair are now working on understanding the mechanism by which copper might cause beta-amyloid to accumulate in the brain.

Ashley Bush and colleagues at Harvard Medical School have previously proposed a different mechanism by which metals like copper and zinc could cause Alzheimer’s (New Scientistprint edition, 3 August 2002). They have suggested that the metals may cause beta-amyloid to turn into a rogue enzyme, catalysing the production of hydrogen peroxide, which then damages brain cells.

SOURCEhttp://www.newscientist.com/article/dn4045-copper-link-to-alzheimers-disease.html

***

It appears that many of fluoride’s effects, and those of the aluminofluoride complexes are mediated by activation of Gp, a protein of the G family. G proteins mediate the release of many of the best known transmitters of the central nervous system. Not only do fluorides affect transmitter concentrations and functions but also are involved in the regulation of glucagons, prostaglandins, and a number of central nervous system peptides, including vasopressin, endogenous opioids, and other hypothalamic peptides. The AlFx binds to GDP and ADP altering their ability to form the triphosphate molecule essential for providing energies to cells in the brain. Thus, AlFx not only provides false messages throughout the nervous system but, at the same time, diminishes the energy essential to brain function.

Fluorides also increase the production of free radicals in the brain through several different biological pathways. These changes have a bearing on the possibility that fluorides act to increase the risk of developing Alzheimer’s disease. Today, the disruption of aerobic metabolism in the brain, a reduction of effectiveness of acetylcholine as a transmitter, and an increase in free radicals are thought to be causative factors for this disease. More research is needed to clarify fluoride’s biochemical effects on the brain.

Anatomical Changes in the Brain

Studies of rats exposed to NaF or AlF3 have reported distortion in cells in the outer and inner layers of the neocortex. Neuronal deformations were also found in the hippocampus and to a smaller extent in the amygdala and the cerebellum. Aluminum was detected in neurons and glia, as well as in the lining and in the lumen of blood vessels in the brain and kidney. The substantial enhancement of reactive microglia, the presence of stained intracellular neurofilaments, and the presence of IgM observed in rodents are related to signs of dementia in humans. The magnitude of the changes was large and consistent among the studies. Given this, the committee concludes further research is warranted in this area, similar to that discussed at a February 2-3,1999, EPA workshop on aluminum complexes and neurotoxicity and that recommended for study by NTP (2002).

RECOMMENDATIONS

On the basis of information largely derived from histological, chemical, and molecular studies, it is apparent that fluorides have the ability to interfere with the functions of the brain and the body by direct and indirect means. To determine the possible adverse effects of fluoride, additional data from both the experimental and the clinical sciences are needed.

  • The possibility has been raised by the studies conducted in China that fluoride can lower intellectual abilities. Thus, studies of populations exposed to different concentrations of fluoride in drinking water should include measurements of reasoning ability, problem solving, IQ, and short-and long-term memory. Care should be taken to ensure that proper testing methods are used, that all sources of exposure to fluoride are assessed, and that comparison populations have similar cultures and socioeconomic status.
  • Studies of populations exposed to different concentrations of fluoride should be undertaken to evaluate neurochemical changes that may be associated with dementia. Consideration should be given to assessing effects from chronic exposure, effects that might be delayed or occur late-in-life, and individual susceptibility (see Chapters 2 and 3 for discussion of subpopulations that might be more susceptible to the effects of fluoride from exposure and physiologic standpoints, respectively).
  • Additional animal studies designed to evaluate reasoning are needed. These studies must be carefully designed to measure cognitive skills beyond rote learning or the acquisition of simple associations, and test environmentally relevant doses of fluoride.
  • At the present time, questions about the effects of the many histological, biochemical, and molecular changes caused by fluorides cannot be related to specific alterations in behavior or to known diseases. Additional studies of the relationship of the changes in the brain as they affect the hormonal and neuropeptide status of the body are needed. Such relationships should be studied in greater detail and under different environmental conditions.
  • Most of the studies dealing with neural and behavioral responses have tested NaF. It is important to determine whether other forms of fluoride (e.g., silicofluorides) produce the same effects in animal models.

SOURCEhttp://www.nap.edu/openbook.php?record_id=11571&page=222 //http://www.nap.edu/openbook.php?record_id=11571&page=223

***

According to ‘NSF/ANSI Standard 60: Drinking Water Chemicals – Health Effects’ (NSF 60), the main impurities of concern for fluoride chemicals are arsenic, cadmium, copper and lead… According to NSF 60, other impurities that have been detected in less than 1% of fluoride chemicals include antimony, barium, beryllium, chromium, mercury, selenium and thallium.

SOURCEhttp://www.health.qld.gov.au/ph/documents/ehu/fluoride_codepractice.pdf (pp. 54-55,refer to TABLES 1 – 3) // Also see: http://afamildura.wordpress.com/fluoridation-chemicals/

***

Sodium fluoride as a wood preservative, pesticide, insecticide, fungicide, rodenticide; also used in the manufacture of vitreous enamels, casein glues, coated papers and toothpaste…Sodium fluorosilicate is used in aluminium and beryllium refining and as laundry soap.

SOURCEhttp://www.deir.qld.gov.au/workplace/resources/pdfs/ddp-fluorideguide.pdf

DRUM ROLL…

Alzheimer ’s Australia CEO Glenn Rees says the

dementia epidemic is not coming, it’s arrived.

He tells David Hutchins the government needs a massive war chest to fight it.

SOURCEhttp://www.fightdementia.org.au/dementia-epidemic-needs-500-million-war-chest-.aspx

***

The key to maintaining good dental health for someone with dementia is: Regularly using fluorides on natural teeth. This includes fluoridated tap water, toothpastes, mouth rinses and gels.

SOURCEhttp://www.fightdementia.org.au/services/dental-care.aspx

BUT THERE IS NO POSSIBLE CONNECTION TO WATER FLUORIDATION…

BECAUSE, A BUNCH OF DENTISTS SAID SO…

NOW, GO BACK TO SLEEP…

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